The intent is to generally summarize the solutions to allow people to choose a direction to invest further effort. It is further not meant to be a full and complete overview of WINE/Virtual Machines/dual booting/etc. This is not indented to be a 'catch-all' answer to 'how do I overcome game X's difficulties when running under solution Y.' The existence of this answer does not mark every other MacOS gaming question on this topic as a duplicate. Please note: This is intended as general advice to a non-technical audience. When attempting to play a Windows game on a Mac OS-based machine, you have several options, each with its drawbacks and strengths. However, it is possible to play PC games on a Mac.
In the general case, you normally can't expect to go to your favorite game shop, pick up a PC game, take it home, and expect to be able to put the game on your Mac and have it run.